Also known as glycogenosis or dextrinosis, glycogen storage disease (GSD) are a group of rare genetic disorders characterised by an inability to metabolise glycogen, which is the stored form of sugar in the body. These diseases are known to affect cats, horses, and humans.
- Normally when the cat eats, the body breaks down the food and blood levels sugar rise. The pancreas secretes insulin, and blood containing glucose enters the cells of the liver (known as hepatocytes) and to a lesser degree the heart, brain, skeletal and smooth muscles.
- When the body runs low on glucose, it can draw on those reserves, converting glycogen back into glucose. Only the liver can supply other organs, but stored glycogen in the heart, brain, skeletal and smooth muscles can be used internally.
- This conversion from glucose to glycogen occurs due to an enzyme known as glycogen branching enzyme (GBE) which produces a branching structure. Cats with GSD have are unable to obtain glucose molecules from stored glucogen because they have a defect in or absence of the glycogen branching enzyme, which means an abnormal form of glycogen is stored in the tissues which is unable to be released in the form of glucose molecules when needed. This leads to a build up of stored glycogen within the tissues of the liver, brain, and muscles while blood sugar levels become dangerously low.
Glycogen builds up in the tissues, especially the liver, heart, and muscles leading to an increase in size and eventually scarring (cirrhosis) along with organ dysfunction.
Only type IV affects cats and it is an inherited condition found in Norwegian Forest cats. It is caused by a recessive gene, which means both parents carry the gene (known as GBE 1), but as they only have one copy, do not have the condition themselves. A copy from both parents is necessary for the disease to occur.
What are the symptoms of glycogen storage disease in cats?
Kittens may die at in the womb or at birth from hypoglycemia (low blood sugar levels). Those who do survive will develop normally until they are around 5 to 7 months of age when symptoms develop.
Common symptoms of glycogen storage disease include:
- Persistent pyrexia (fever) which is unresponsive to treatment
- Muscle tremors
- Bunny hopping gait
- Muscle weakness eventually turning into atrophy (wasting)
- Muscle paralysis
How is glycogen storage disease diagnosed in cats?
Your veterinarian will perform a complete physical and neurological examination of your cat and obtain a medical history from you. His index of suspicion may be raised due to the breed of your cat.
- Standard tests including complete blood count, biochemical profile, and urinalysis. Hypoglycemia may be revealed. Elevated liver enzymes may also be revealed.
- Ultrasound of the organs may display an enlargement of the liver, kidneys or heart.
- Echocardiogram to evaluate the heart.
- A definitive diagnosis can be made by a DNA test.
How is glycogen storage disease treated?
Unfortunately, there is no cure for glycogen storage disease. This disease progresses over months with most affected cats dying or being euthanised by 12-15 months of age.
Preventing glycogen storage disease in cats:
There is a DNA test to determine if cats carry the defective gene. Cats who are known carriers should not be bred with, however as two genes are required for the condition to develop, carrier cats can be desexed and live a full life.