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Eosinophilic Granuloma Complex 

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What is an eosinophil: 

A type of white blood cell that participates in allergic reactions and helps to fight certain parasitic infections.

What is a granuloma: 

A granuloma is an inflammatory lesion containing granulocytes. 

What is Eosinophilic Granuloma Complex & what are the symptoms?

Eosinophilic granuloma complex is a commonly observed in which a group of skin lesions affect the cat, mostly on the mouth, face & skin. There are three different lesions.  

  • Indolent ulcer (also known as eosinophilic ulcer or rodent ulcer): This affects cats of all breeds & ages, although is seen three times as often in females as it is in males. Lesions most often occur on the upper lip (around the middle area), but can also be observed on the tongue. They appear as a raised, thickened red/brown ulcer which is well defined & glistening. Generally while they may look so, they are not painful to the cat. 

  • Eosinophilic plaque: Once again, this is seen in cats of any breed or sex. The lesion can appear on any part of the body, but most often are seen on the abdomen or thighs. They appear as red, well defined, raised, hairless lesions which may be ulcerated. 

  • Eosinophilic granuloma. (Also known as Linear granuloma or Collagenolytic granuloma):  This is more commonly seen in males than females, and teenage cats (under 1 year of age) are most often affected. Commonly seen on the back legs lesions (although they can appear anywhere, appear as long, straight, thin lines which are raised & inflamed, and pinkish-yellowish in colour. Distribution on the face is seen as swellings & nodules on the bottom lip & the cat has a "fat chinned" pout. Footpads may also be affected by eosinophilic granuloma.

What causes eosinophilic granuloma complex?

No one cause has been found for eosinophilic granuloma complex. It has been suggested it is a reaction to flea bite hypersensitivity, food hypersensitivity or inhalant allergy. 

The eosinophil's job is to attack parasites. It is attracted to areas where parasites occur & once there, it will release biochemicals to destroy the parasite. In cats with eosinophilic granuloma complex, eosinophils are called to the site of an allergic response & the biochemicals cause damage to the local collagen.

How is it diagnosed?

Visual examination of the ulcers will be performed by your veterinarian. 

How is it treated?

If it is at all possible, identify the underlying cause & treat accordingly. 

  • Steroids

  • Antihistamines

  • Ensuring the cat is parasite free

  • Avoiding & or eliminating suspected allergens

If lesions are unresponsive, surgical excision or antibiotics may be tried. 

If the cause is believed to be caused by flea bite hypersensitivity, food allergies or inhalant allergies flea control, hypersensitization or feeding a hypoallergenic diet may be recommended. 

References: 

The Cornell Book of Cats. 

Maristavet  

Please note:

The medical articles on this site have not been written by a veterinarian & should not be considered a replacement for a veterinarian visit. The articles are provided for informative purposes only.

Always seek immediate veterinary advice for any problems (health or behavioral) in your pets. 

While great care has been made in the creation of these articles, we cannot guarantee the accuracy or omissions on these pages. If in any doubt whatsoever, seek professional medical advice. 

 


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