Hypertrophic cardiomyopathy is a condition in which a portion of the heart becomes thickened which makes it hard for the heart to work effectively.
Symptoms include lethargy, exercise intolerance, difficulty breathing, weight loss, loss of appetite, abnormal heart sounds.
Treatment is based on managing symptoms as well as slowing down the progression of the disease and may include beta-blockers and ACE inhibitors, diuretics low salt diet and restrict exercise.
Feline hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats and as the name would suggest, the main feature of HCM is an excessive thickening of the left ventricular wall, papillary muscles, and septum. Cardio=heart, myopathy=muscle disease and hypertrophic=thickened. The heart is a pump with four chambers, two on the left and two on the right. Each side has two chambers, a ventricle, and atrium, the ventricles serve as pumping chambers and the atria as receiving chambers.
- The left atrium and left ventricle.
- The right atrium and right ventricle.
The right atrium receives deoxygenated blood from the body which is pumped into the right ventricle. From here, the blood is pumped into the lungs where it is oxygenated. The left atrium receives the oxygenated blood, pumping it into the left ventricle, from here, the blood is pumped into the rest of the body.
In some cases, systemic diseases can lead to a thickening of the heart. These include high blood pressure (hypertension), hyperthyroidism and acromegaly.
- Enlargement of the heart wall causes stiffening of the muscle, preventing the heart from expanding to receive blood properly.
- As the walls thicken, the size of the heart chambers decreases resulting in less blood pumping through the heart. The heart has to work harder, beating faster to maintain blood flow throughout the body.
- It may also reduce the ability of the valves to work properly, and in some circumstances obstruct the flow of blood out of the heart.
- Arrhythmias, irregularities of the heartbeat and conduction disturbances are also common complications of hypertrophic cardiomyopathy. The thickened wall sometimes distorts one leaflet of the mitral valve, causing it to leak.
- As the left ventricle shrinks and stiffens due to a thickening of the wall, it is less able to accept as much blood, this results in a build up in the left atrium and the lungs and the lining of the chest, leading to congestive heart failure and pulmonary edema, making breathing difficult.
- Blood clots can form in the left atrium and be carried into the systemic arterial system, most often lodging in the terminal artery, causing paralysis of the hind legs.
The cause of HCM hasn’t been established. However, it is known that HCM in Maine Coons (MYBPC3-A31P) and Ragdolls (MYBPC3-R820W) is inherited as an autosomal dominant trait with incomplete penetrance. Cats have two sets of genes, one from the mother, one from the father. If the cat inherits one mutant allele (an allele is an alternative form of a gene), he is at greater risk of developing HCM, and an even higher chance if he inherits two mutant alleles (one from each parent). Around 30% of Maine Coons have this genetic mutation.
There is anecdotal evidence that HCM may be inherited in Norwegian Forest Cats, Scottish Folds, and American Shorthairs, but this is not the same gene mutation as the ones the Maine Coon or Ragdoll have, but possibly similar. However, there is a higher incidence in domestic cats.
A cat with hypertrophic cardiomyopathy may display no symptoms at all but die suddenly and unexpectedly. Symptoms can develop over time and be subtle. Many symptoms are due to fluid build up in the lungs and pleural space make breathing more difficult.
- Rapid laboured and noisy breathing
- Decreased activity
- Irregular heart rhythm
- Heart murmur
- Weight loss
- Blue-tinged gums due to a lack of oxygen circulating and/or pulmonary edema and pleural effusion.
- Lameness or paralysis of the hind legs due to saddle thrombosis.
- Sudden death
As noted, some breeds can inherit a genetic mutation making them more likely to develop HCM.
The disease occurs most often in middle-aged cats and older. Male cats are more prone to developing HCM as are overweight cats.
A physical examination may reveal abnormal heart or lung sounds, irregular or gallop heart rhythm or a heart murmur, this may well be the first indication that your cat has HCM.
- Echocardiogram (heart ultrasound) is the best diagnostic tool for HCM. Your veterinarian will evaluate the size, shape, and functioning of the heart. The thickening can range from mild to pronounced.
- X-Ray can show if there is fluid in the chest and heart enlargement.
- Electrocardiogram – This test records the electrical activity of the cat’s heart to check for irregular in the rhythm.
- Blood tests including a complete blood count and chemistry panel. These can help provide information on the function of other organs. This information is important when determining methods of treatment.
- Thyroid function tests to determine if the cause is due to hyperthyroidism.
- Arterial blood pressure to check for hypertension.
- A genetic test is available for the Maine Coon and Ragdoll HCM gene defect.
Asymptomatic cats may require no treatment, but your veterinarian will want to monitor him/her closely. It is not possible to cure HCM, treatment is managing symptoms and slowing down the disease.
- The thick ventricles of HCM contract and relax abnormally, and to assist the relaxation phase some drugs may be necessary. Beta-blocking drugs such as atenolol or propranolol to slow down the heart rate, this gives the heart more time to fill the chambers.
- ACE inhibitors and calcium blocking channels to slow down the progression of the disease.
- Diuretics to treat congestive heart failure.
- Controlled doses of blood-thinning drugs such as aspirin for cats who have a high risk of clot formation.
- Thoracocentesis (pleural tap) to remove fluid build up from the pleural space.
- Placing your cat on a low salt diet.
- Restricting activity also reduces the strain on the heart and your veterinarian may prescribe a period of cage rest.