Melanoma is a rare type tumour which arises from the pigment producing melanocytes. They can be benign or malignant. 50% are malignant (malignant melanomas) and highly metastatic, which means they readily spread to other parts of the body such as the lungs, liver, brain, spleen and bone.
Malignant melanoma stats:
- Melanomas comprise of less than 2% of all feline tumours.
- Ocular and oral melanomas tend to be more malignant than skin melanomas.
- 1% of oral tumours and less than 0.5% of skin tumours, they tend to develop on highly pigmented parts of the skin.
- Malignant melanomas are the most common type of intraocular tumour.
There is no breed or sex predilection, the mean age is 11-12 years.
Ginger and red cats are commonly affected by benign melanocytic hyperplasias, or lentigo, in which heavily pigmented flat spots appear on the lips, nose and eye margins. Spots increase in numbers as the cat ages. While normal, it is important a veterinarian evaluate any lumps and/or pigment changes to rule out a malignant melanoma.
Benign pigmented spots can also develop in the eyes (iris melanosis). While an iris melanosis is benign, in some cases can transform into a malignancy. Cats with an iris melanosis should be regularly evaulated by a veterinarian or specialist veterinary ophthalmologist to monitor its progress. Glaucoma (increased intraocular pressure) is also a risk factor for cats with iris melanosis.
Unlike humans, sun exposure doesn’t appear to increase the incidence of melanoma in cats, however, sun exposure does cause squamous cell carcinoma, so it is important to take care, especially with pale cats or cats with sparse fur (such as the Sphynx).
It is possible that there is a genetic predisposition to malignant melanoma.
Melanoma has been induced in cats who were experimentally injected with a strain of feline sarcoma virus.
Common melanoma sites include the head, eyes, eyelids, oral cavity and toes. Ocular melanomas are more common than skin or oral melanomas and are more likely to be malignant. Approximately 50% of skin melanomas are benign.
Obviously, symptoms will vary depending on the location of the tumour.
- Single, raised growth which grows rapidly. Pigmentation may or may not occur.
- Common locations include the head, ears, toes and scrotum of intact males.
- Bleeding and ulceration.
- Pigmented, raised spots in iris (the coloured part) of the eye which have a velvety appearance.
- Enlargement of the eyeball.
- Distortion of the pupil (the black portion of the eye).
- Excessive tearing.
- Bad breath.
- Reluctance to eat.
- Facial swelling.
- Bleeding and ulceration.
- Weight loss.
As the tumour spreads through the body, additional symptoms can develop such as:
- Weight loss
- Difficulty breathing
Your veterinarian will perform a complete physical examination of your cat and obtain a medical history from you including how long the lump has been present and any other symptoms you have noticed.
Diagnostic tests will be necessary to both evaluate your cat’s overall health as well as to diagnose the melanoma. These will include:
Baseline tests: Biochemical profile, complete blood count and urinalysis to evaluate the organs and the health of the cat.
Ophthalmoscope or slit lamp examination: For cats with suspected ocular (eye) melanoma, the veterinarian will carefully and thoroughly examine the eye.
Fine needle aspirate: A needle removes a small sample of the tumour for microscopic evaluation.
Excisional biopsy: If the fine needle aspirate does not provide conclusive results, or if the veterinarian strongly suspects a malignant melanoma, surgical removal, with a wide margin may be performed under anethesia. The tumour will be sent to a pathologist for evaluation and staging.
Xray or ultrasound: If the cat has a malignant melanoma, a thoracic (chest) and abdominal xray or ultrasound will be necessary to determine if the tumour has spread.
The earlier the treatment starts, the better. Treatment depends on the location of the tumour, sadly malignant melanomas are very aggressive and the prognosis is poor even with treatment.
Surgery: If the size and location permit, surgical removal of skin melanomas with a wide margin. Ocular melanomas will necessitate surgical removal of the eye (enucleation). Affected local lymph nodes will also be removed at this time. All tissues will be sent to a laboratory for histopathology (microscopic evaluation of the tissues).
Laser therapy: To treat small iris melanomas. A diode laser destroys ocular tumour cells.
Electrochemotherapy: An emerging therapeutic treatment which shows great promise for the treatment of skin tumours. Chemotherapy drugs are poorly absorbed, this treatment allows for better penetration by delivering electric impulses into the tumour after administration of chemotherapy
Radiation therapy: If it is not possible to remove the tumour, radiation can help to shrink it.
Melanoma vaccine: This vaccine uses human DNA to stimulate the cat’s immune system to recognise the melanoma as foreign. The vaccine routinely used in dogs and horses but there is not much research on the effectiveness of the vaccine in cats. Hopefully this vaccine will provide a treatment for cats in the near future.
It will be necessary for your cat to wear an Elizabethan collar at home to prevent trauma to the surgical site. The veterinarian will also prescribe painkillers and antibiotics, administer as prescribed.
Keep the cat inside while it heals.
Watch for signs of infection such as redness, swelling and oozing. Speak to your veterinarian if you notice any changes.
Regular follow up visits will be necessary to evaluate the cat. Follow up xrays or ultrasound may be necessary.
If you notice the tumour re-grows, seek veterinary attention immediately.