|What is myelodysplasia? Causes Symptoms Diagnosis Treatment Prognosis|
At a glance:
About: Myelodysplasia is a group of diseases caused by a dysfunction of blood cell production in the bone marrow. It can affect red or white blood cells and platelets. Red blood cells are most commonly affected.
Causes: FIV and FELV, exposure to toxins such as lead, chemotherapy, copper deficiency and myeloid leukemia. In most cases, it will not be possible to determine the cause.
Symptoms: There can be a variety of symptoms depending on the cells affected. Anemia: pale gums, lethargy, rapid breathing and heartrate. Leukopenia: Mouth ulcers, recurrent infections, fever and fatigue. Thrombocytopenia: increased bleeding, black tarry stools.
Diagnosis: Complete physical examination, accompanying symptoms and history. A bone marrow biopsy can confirm diagnosis. This procedure is performed under general anesthetic.
Treatment: Blood transfusions, antibiotics (where needed), hematopoietic growth factors, immunosuppressive drugs, low dose chemotherapy. The only cure for myelodysplasia is a bone marrow transplant (rare).
Myelodysplasia syndrome (MDS) is a group of blood diseases arising from dysfunction from the hematopoietic stem cells which start to produce abnormal immature myeloid cells both of which are located in the bone marrow. Myelo=marrow (myeloid cells), dys=abnormal, plasia=appearance.
It is characterised by cytopenias (cytopenia is the medical term for a reduction in any of the three types of blood cells) in the peripheral blood and dysplastic changes in the bone marrow cells.
In cats with myelodysplasia, the myeloid cells begin to produce abnormal immature blasts, which can’t mature and develop as normal blood cells should or if specialised blood cells are produced they die shortly before or after leaving the bone marrow. Three types of blood cell are produced by the myeloid cells.
Red blood cells (erythrocytes) – These cells transport oxygen around the body. Anemia is a reduced number of red blood cells.
White blood cells (leukocytes) – Responsible for fighting infection. Leukopenia is a reduced number of white blood cells.
Platelets (thrombocytes) – Not cells but cell fragments, platelets are a part of the blood clotting process, forming a plug to stop bleeding. Thrombocytopenia is a reduced number of platelets.
Below is a very basic description of the development of blood cells, which is known as hematopoiesis.
Normal blood cell production
Multipotential hematopoietic stem cell (hemocytoblast) > Immature myeloid cells > Immature specialised cells (red, white, megakaryocyte, the latter will form platelets) Specialised cells mature (red, white or platelets) which are released into the bloodstream.
Myelodysplasia (abnormal) cell production
Hematopoietic stem cell > Abnormal immature myeloid cells can crowd out normal stem cells as they are often no longer able to move onto the next step and differentiate into red, white blood cells and platelets, or they do become immature specialised cells but are abnormal > Specialised cells (red, white cells or platelets) aren’t produced, or are produced but are abnormal and die shortly before or after being released into the bloodstream
Normally the percentage of myeloid cells in the bone marrow is between 2-3%, cats with myelodysplasia often (but not always) have a much higher number of abnormal immature myeloid cells. Once that number goes over 20%, the disease has progressed to acute myeloid leukemia (AML). That is why myelodysplasia is sometimes referred to as preleukemia.
Myelodysplasia can involve one cell line, for example red blood cell only, or multiple cell lines. Erythrocytes (red blood cells) are the most common cell involved.
Refractory cytopenia with unilineage dysplasia (RCUD) means that your cat has low numbers of one type of blood cell. For example:
- Refractory thrombocytopenia means he has low blood platelets but normal red and white blood cells.
- Refractory anemia means he has low red blood cells but normal white blood cells and platelets.
- Refractory leukopenia means he has low white blood cells but normal red blood cells and platelets.
Refractory cytopenia with multilineage dysplasia (RCMD) means that more than one type of blood cell is affected.
There are no age or gender predilections with this myelodysplasia, Persians, and Birmans appear to be slightly over-represented. Cats with feline immunodeficiency disease and feline leukemia are at greater risk of developing myelodysplasia. It may be primary or secondary.
Primary myelodysplasia arises from mutations in the stem cells.
Secondary myelodysplasia is due to myeloid leukemia, copper deficiency, exposure to toxins such as lead, nutritional deficiency or certain drugs such as chemotherapy or radiotherapy and the feline leukemia virus.
Symptoms depend on the affected cell line(s), but may include:
Anemia (red blood cells)
Leukopenia (white blood cells)
- Increased bleeding such as nosebleed or gums
- Black tarry stools due to internal bleeding
If more than one cell line is affected, your cat will experience a combination of the above symptoms.
Your veterinarian will perform a complete physical examination of your cat and obtain a medical history from you including any drug therapies your cat has received. He will need to perform some tests to determine the cause. These may include:
Baseline tests such as complete blood count, biochemical profile and urinalysis. These can help to show how your cat’s organs are functioning if an infection is present and give a count of the types of blood cells, which will reveal anemia, leukopenia, thrombocytopenia or a combination. There may also be abnormally formed cells in the blood. These will give your veterinarian a preliminary diagnosis.
As there are many causes of anemia, leukopenia, and thrombocytopenia, he will need to perform some additional tests to narrow down the cause.
Bone marrow biopsy: Your cat will be anesthetised and a needle will be inserted into the bone of the pelvis or the femur and into the centre where the bone marrow is located. The sample will be sent to a laboratory for evaluation. The normal percentage of myeloid cells within the bone marrow is around 2-3%, a cat with myelodysplasia may have a much higher percentage of myeloid cells although it is possible for the myeloid cell numbers to be normal or even reduced.
Blood smears: To examine the morphology of the circulating blood cells where abnormalities may be found.
Treatment depends on the type of myelodysplasia and the severity of the condition.
Whole blood or platelet transfusions to maintain blood cell and platelet counts. Platelets don’t live for long so transfusions of platelets will need to be more frequent than whole blood. Cats who receive whole blood are at increased risk of iron overload.
Broad-spectrum antibiotics where needed.
Hematopoietic growth factors are proteins which can stimulate cell differentiation and production. Erythropoietin (EPO), granulocyte colony-stimulating factor (G-CSF) and granulocyte-monocyte colony stimulating factor (GM-CSF).
Immunosuppressive drugs may be prescribed, in some cases, the cat’s immune system slows down production of blood cells.
Low dose chemotherapy may be administered orally or via injection, these drugs can help the cells of the bone marrow develop normally by killing rapidly dividing (abnormal) cells, and/or help prevent the disease progressing to acute myeloid leukemia (AML).
There only cure for myelodysplasia is a bone marrow transplant. This is used in some human cases, usually when the patient is young, however, it is only experimental in cats. The procedure involves high doses of chemotherapy to destroy the patient’s own dysfunctional bone marrow cells, followed by a bone marrow transplant from a healthy cat. The procedure