Pyometra in Cats – Causes, Symptoms & Treatment

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Pyometra in cats

What is pyometra?

Pyometra (pus-filled uterus) is a serious and life-threatening infection associated with a condition known as cystic endometrial hyperplasia (CEH). It used to be thought that female cats were induced ovulators, meaning ovulation occurs when the cat mates, however, it is now believed that the female ovulates spontaneously (without mating) and several ovulations may have occurred without the owner being aware.

Normally if no pregnancy occurs, the lining will regress at the end of the heat cycle, however, frequent heat cycles, spontaneous ovulation and administration of progestins (used to control heat cycles in cats) may result in abnormal endometrial growth.   In this situation, prolonged exposure to progesterone results in hyperplasia (enlargement) of the endometrium and causes the endometrium glands to become cystic. Other influencing factors such as the inhibition of myometrial (uterine wall) contractions, the cervix is closed, white blood cell activity is decreased at this time, creating an ideal environment for bacteria to grow. E. coli and Streptococcus spp are most commonly isolated from the cat, however, other bacteria can also occur.

Pyometra can occur in any unspayed female, however, there is a higher incidence in cats over five years of age. Most cases of pyometra occur within 60 days of the female being in estrus.


Pyometra usually appears 6 – 8 weeks after the queen goes out of heat. It is a life-threatening infection and requires immediate veterinary attention. Pyometra may come on quickly, or take several months to fully develop.

There are two types of pyometra, open and closed.

  • Open pyometra: The cervix is open, and pus drains out of the vagina. This is often cream, pink or brown in colour, and has an offensive odour.
  • Closed pyometra: As the uterus is closed, pus is unable to drain from the vagina and therefore collects in the uterus.

It is important to note that all cases of pyometra are medical emergencies but closed pyometra is far more dangerous and life-threatening. Both forms of pyometra require immediate veterinary attention. Pyometra can lead to organ damage and septicemia.

As well as the possible discharge from the vagina, your cat may display some or all of the below symptoms:


Your veterinarian will perform a physical examination of your cat and ask for a medical history such as when her last heat cycle was. He may observe the discharge of pus from the vagina, and be able to feel the enlarged uterus.

Ultrasound can confirm diagnosis.


  • Ovariohysterectomy (desexing/spaying) is the best option.
  • Antibiotics to control the infection.
  • IV fluids to treat dehydration.
  • Prostaglandin treatment if the cat is required for breeding. This causes contraction of the uterus and the cervix to relax, which assists in evacuation of the pus. There may be side effects from the prostaglandin such as vomiting, diarrhea, restlessness, panting, shock.
  • Where possible, culture the pus so that the cat can receive the most effective antibiotics.
  • There is a chance that treatment will not be successful, and for pyometra to reoccur in cats treated for pyometra but not spayed.


Pymoetra is 100% preventable by spaying females.



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